Turmeric 95% extract BioPerine

Quantities in recommended daily dose (= 2 capsules)

*DV – percentage daily value

Ingredients: Dry extract of Turmeric rhizome (Curcuma longa) containing at least 95% curcuminoids, thickener: hydroxypropyl methyl cellulose (capsules), anti-caking agent: microcrystalline cellulose, dry extract of Black Pepper fruit (Piper nigrum), anti-caking agent: cellulose powder (ARBOCEL® A300).

BioPerine® is a 95% extract obtained from black pepper grown in fertile, humid soils in the southern regions of India. The extract piperine, known as BioPerine® in its patented form, is the only black pepper extract that has demonstrated its safety and efficacy through clinical studies in the United States for dietary use (GRAS status).

You can find more about the standardized and patented BioPerine® black pepper extract here: http://www.bioperine.com/

Analiza na zdravstvenu ispravnost: Kurkuma 95% ekstrakt BioPerine

• G Shoba, D Joy, T Joseph, M Majeed, R Rajendran, P S Srinivas: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
  • Result: The medicinal properties of curcumin obtained from Curcuma longa L. cannot be fully utilized due to its poor bioavailability caused by rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of liver and intestinal glucuronidation, on the bioavailability of curcumin in healthy volunteers was evaluated. In humans, after a dose of 2 g of curcumin alone, serum levels were either undetectable or very low. Concurrent administration of 20 mg of piperine resulted in much higher concentrations within 0.25 to 1 hour after ingestion, with a 2000% increase in bioavailability. The study demonstrates that at the doses used, piperine increases serum concentration, absorption rate, and bioavailability of curcumin in rats and humans without adverse effects.
• Hiwale AR, Dhuley JN, Naik SR. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp Biol. Mar 2002;40(3):277-281.
  • Result: Concurrent administration of piperine, an alkaloid isolated from Piper nigrum L., significantly increased the bioavailability of beta-lactam antibiotics, amoxicillin trihydrate, and cefotaxime sodium. The increased bioavailability could be attributed to piperine’s effect on microsomal enzymes or the enzymatic system involved in metabolism.
• Araujo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 2001;96:723-8.
  • Result: There are several data in the literature indicating a wide range of pharmacological activities of Curcuma longa L. (Zingiberaceae), which include anti-inflammatory, antiviral effects against human immunodeficiency, antibacterial, antioxidant, and nematocidal effects. Curcumin is the main component of Curcuma longa L., responsible for its biological activity. Other extracts of this plant have also shown potency. In vitro, curcumin exhibits antiparasitic, antispasmodic, anti-inflammatory, and gastrointestinal effects; it also inhibits carcinogenesis and cancer growth. In vivo, experiments demonstrate the antiparasitic and anti-inflammatory power of curcumin and extracts of C. longa L. through parenteral and oral administration in animal models.
• Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 2007;47(8):735-748.
• Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr. Aug 2004;134(8):1948-1952.
• Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp Ther. Jan 1985;232(1):258-262.
• Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption–an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol. Jan 1998;36(1):46-50.
• Zeng, Y., Qiu, F., Takahashi, K., Liang, J., Qu, G., and Yao, X. New sesquiterpenes and calebin derivatives from Curcuma longa. Chem.Pharm Bull.(Tokyo) 2007;55(6):940-943
• Zhang, L., Fiala, M., Cashman, J., Sayre, J., Espinosa, A., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G., and Rosenthal, M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer’s disease patients. J Alzheimers.Dis. 2006;10(1):1-7.
• Allen, S. W., Mueller, L., Williams, S. N., Quattrochi, L. C., and Raucy, J. The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Drug Metab Dispos. 2001;29(8):1074-1079.
• Antony S, Kuttan R, Kuttan G. Immunomodulatory activity of curcumin. Immunol Invest 1999;28:291-303..
• Appiah-Opong, R., Commandeur, J. N., Vugt-Lussenburg, B., and Vermeulen, N. P. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 6-3-2007;235(1-2):83-91.
• Baum L, Lam CW, Cheung SK, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease (letter). J Clin Psychopharmacol 2008;28:110-3.
• Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Alt Med Rev 2010:15:337-4.
• Calaf GM, Echiburú-Chau C, Wen G, Balajee AS, Roy D. Effect of curcumin on irradiated and estrogen-transformed human breast cell lines. Int J Oncol. 2012;40(2):436-42
• Carroll RE, Benya RV, Turgeon DK, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila) 2011;4:354-64.
• Choi, B. H., Kim, C. G., Lim, Y., Shin, S. Y., and Lee, Y. H. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett. 1-18-2008;259(1):111-118
• Deeb D, Xu YX, Jiang H, et al. Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol Cancer Ther 2003;2:95-103.