Q10 Natural Complex

Levels of coenzyme Q10 begin to decrease in the 30s. A small amount of coenzyme Q10 can be absorbed through food; for the daily requirement of 100 mg, approximately 3.5 kg of beef, 120 cans of sardines, 60 avocados, or 33 tablespoons of olive oil would need to be consumed. When there is a deficiency of coenzyme Q10 in the body, aging accelerates, the immune system weakens, and energy levels and endurance decrease.

Q10 Natural Complex is a dietary supplement that, along with a significant amount of highly purified 98% coenzyme Q10, contains a combination of active ingredients of natural origin – beetroot extract, garlic extract, rosehip fruit extract (a natural source of vitamin C), and soybean seed extract (a natural source of vitamin E). Additionally, the formulation is enhanced with chromium and B vitamins. There are a total of 10 active ingredients.

The daily dose is provided by just one capsule with a high 100 mg of coenzyme Q10, which in this amount is sufficient for the daily needs of an adult.

Quantities in recommended daily dose (= 1 capsule):

*DV – percentage daily value

Ingredients: dry rosehip fruit extract (Rosa canina) containing 50% vitamin C, coenzyme Q10, thickener: hydroxypropyl methyl cellulose (capsule), dry beetroot root extract (Beta vulgaris), dry garlic fruit extract (Allium sativum), dry soybean seed extract (Glycine max) containing 25% vitamin E, anti-caking agent: magnesium salts of fatty acids, pyridoxine hydrochloride, thiamine hydrochloride, chromium (III) chloride hexahydrate, folic acid (pteroylmonoglutamic acid), cyanocobalamin.

Analiza na zdravstvenu ispravnost: Q10 Natural Complex

• Richelle M., Enslen M., Hager C., et al. Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of beta-carotene and alpha-tocopherol in normocholesterolemic humans. Am J Clin Nutr., 80, 1, 2004, 171-177.
  • Result: 26 men with normocholesterolemia completed a randomized study. Subjects consumed daily, for 1 week each, one of the following 3 supplements: a low-fat milk-based drink (control) or the same drink supplemented with 2.2 g equivalents of either free plant sterols or sterol esters. During this supplementation period of 1 week, subjects maintained a standardized diet. Both milk enriched with plant sterols caused a similar (60%) reduction in cholesterol absorption. Free plant sterols and plant sterol esters reduced the bioavailability of beta-carotene by approximately 50% and alpha-tocopherol by approximately 20%. The reduction in beta-carotene bioavailability was significantly lower with free plant sterols compared to plant sterol esters. At the margin of significance (P = 0.054) in the area under the curve, the reduction in alpha-tocopherol bioavailability was also lower with free plant sterols compared to plant sterol esters.
• Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, Menke T, Cani PD, Delzenne NM. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochem Pharmacol. 2009 78(2009)1391-400.
  • Result: The aim of the study was to investigate the effect of the antioxidant coenzyme Q10 (CoQ10) on liver metabolic and inflammatory disorders associated with diet-induced obesity and glucose intolerance. Mice were fed for 8 weeks either a control diet (CT) or a high-fat diet plus 21% fructose in drinking water (HFF). HFF-fed mice showed increased energy expenditure, development of fat mass, fasting glycemia, insulinemia, and impaired glucose tolerance. Treatment with HFF accelerated the expression of genes involved in reactive oxygen species production and inflammation in the liver. CoQ10 supplementation reduced global hepatic mRNA expression of inflammatory and metabolic stress markers without altering obesity and tissue lipid peroxide levels compared to HFF-fed mice. Paradoxically, HFF diets reduced TBARS levels (reflecting lipid peroxides) in the liver, muscles, and adipose tissue compared to the CT group, an effect associated with dietary vitamin E content.
• Kharaeva Z, Gostova E, De Luca C, Raskovic D, Korkina L. Clinical and biochemical effects of coenzyme Q10, vitamin E, and selenium supplementation to psoriasis patients Nutrition 25 (2009) 295–302
  • Rezultat: 58 pacijenata je hospitalizirano, liječeno prema konvencionalnim protokolima i nasumično raspoređeno u četiri skupine. Grupe EP1 i PsA1 suplementirane su koenzimom Q10, vitaminom E (prirodni alfa-tokoferol, 50 mg/dan) i selenom otopljenim u soji lecitin 30-35 d. Skupine EP2 i PsA2 (placebo) primale su sojin lecitin. Klinička stanja procijenjena su parametrima težine. Na početku su pacijenti imali povećano otpuštanje superoksida iz granulocita (10,0 +/- 0,5, 2,9 +/- 0,2 i 1,5 +/- 0,1 nmol/L po 10(6) stanica/h za EP, PsA i davatelje, respektivno), povećane aktivnosti bakar/cink-superoksid dismutaze i katalaze u granulocitima u bolesnika s EP i smanjene u bolesnika s PsA, smanjena aktivnost bakar/cink-superoksid dismutaze (0,3 +/- 0,0, 1,8 +/- 0,1 i 2,2 +/ – 0,2 U/mg proteina za EP, PsA i donore, redom) i promijenjenu aktivnost katalaze u psorijatičnom epidermisu. Razine nitrita/nitrata u plazmi bile su veće od normalnih u bolesnika s psorijazom. Suplementacija je rezultirala značajnim poboljšanjem kliničkih stanja, što je odgovaralo bržoj normalizaciji markera oksidativnog stresa u odnosu na placebo.
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• Hathcock JN, Shao A. Risk assessment for coenzyme Q10 (Ubiquinone). Regulatory Toxicology and Pharmacology 45 (2006) 282–288
• Piironen V., Toivo J., Puupponen-Pimia R. et al. Plant sterols in vegetables, fruits and berries. J.Sci.Food Agric., 83, 330-337.
• Reiner Ž. The role of nutrition in the prevention and therapy of cardiovascular diseases. Medicus, 17, 1 2008, 93-103.
• Jones P., J., Raeini-Sarjaz M., Ntanios F.,Y., Vanstone C.,A., Feng J.,Y., Parsons W.,E. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res.41, 5, 2000, 697-705.
• Food und Nutrition Board, Institute of Medicine, US National Academy of Science. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy Press, Washington: 2000, pp 95-185.
• Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 1999;69:1086–107.
• Kaegi E. Uncoventioan therapies for cancer: Vitamins A, C and E. The Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative Can Med Assoc J 1998; 158(11): 1483-8.
• Kizhakekuttu TJ, Widlansky ME. Natural antioxidants and hypertension: promise and challenges. Cardiovasc Ther. 28(4) (2010) 20-32.
• Wyman P, Leonard M, Morledge T. Coenzyme Q10: A therapy for hypertension and statin-induced myalgia? Cleveland Clinic Journal of Medicine 77(7) (2010) 435-442.
• Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition. 28(3) (2012) 250-5.
• Pepe S, Marasco SF, Haas SJ, Sheeran FL, Krum H, Rosenfeldt FL. Coenzyme Q10 in cardiovascular disease. Mitochondrion 7S (2007) S154–S167