Natural Stress Off

Stress can be defined as a reaction to a stimulus that disrupts our physical or mental balance. Stress is a natural body response and in small amounts can be stimulating, while chronic, prolonged stress has a negative impact on health. In today’s busy lifestyle, we are constantly exposed to low levels of stress and have almost lost the ability to activate the natural relaxation response.

The consequences of chronic stress can be diverse: from causing anxiety, restlessness, depression, to skin disorders, high blood pressure, certain gastrointestinal syndromes and conditions, asthma, migraine occurrences, fluctuations in blood sugar levels in diabetics, increased incidence of colds, flu, and other acute infectious diseases due to decreased immune response to infectious agents.

Natural Stress Off is enriched with B-group vitamins that are essential for the normal functioning of the nervous system and may be the most important single factor for nerve health. They are crucial for muscle tone in the gastrointestinal tract and for the health of skin, hair, eyes, mouth, and liver.

Quantities in recommended daily dose (= 2 capsules)

*DV – percentage daily value

Ingredients: Theanine, dry extract of Passionflower (Passiflora incarnata), maltodextrin, hydroxypropyl methyl cellulose (capsule), anti-caking agents: talc, cellulose powder (ARBOCEL® A300), pyridoxine hydrochloride, riboflavin, thiamine hydrochloride, cyanocobalamin.

Analiza na zdravstvenu ispravnost: Natural Stress Off

• Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passion Flower Dry Extract Gibbert J, Kreimendahl F, Lebert J, Rychlik R, Trompetter I. Complement Med Res. 2017;24(2):83-89. doi: 10.1159/000464342. Epub 2017 Apr 12. German.
  • Result: Adult patients aged ≤ 95 years diagnosed with ‘restlessness’ were treated for 12 weeks with a dry ethanol extract of passionflower flower. After 12 weeks of treatment, significant improvements in patient resilience were measured. Additionally, the mean value of BDEPQ results significantly decreased (p < 0.001). The mean values of all accompanying symptoms (internal restlessness, sleep disturbance, fatigue, anxiety, lack of concentration, sweating, nausea, tremor, and palpitations) significantly improved. Most patients rated the tolerability of the treatment as "very good" or "good". Three cases of mild side effects (fatigue) were recorded.
• Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, Okubo T, Kunugi H. Acta Neuropsychiatr. 2017 Apr;29(2):72-79. doi: 10.1017/neu.2016.33. Epub 2016 Jul 11.
  • Result: Twenty patients with major depressive disorder were studied. L-theanine (250 mg/day) was added to the current medication of each participant for 8 weeks. Symptoms and cognitive functions were assessed at baseline, 4 weeks, and 8 weeks after L-theanine administration using the 21-item Hamilton Depression Rating Scale, State-Trait Anxiety Inventory (STAI), Pittsburgh Sleep Quality Index (PSQI), Stroop test, and Brief Assessment of Cognition in Schizophrenia (BACS). Depression was reduced after L-theanine administration, particularly among non-remitters at baseline. Anxiety scores decreased after L-theanine administration in the STAI test. PSQI scores also decreased after L-theanine administration among patients who were non-remitters at baseline. Regarding cognitive functions, response latency and error rate decreased in the Stroop test, while verbal memory and executive function improved in the BACS test after consuming L-theanine.
• Open-label observational study of the homeopathic medicine Passiflora Compose for anxiety and sleep disorders. Villet S, Vacher V, Colas A, Danno K, Masson JL, Marijnen P, Bordet MF. 2016 Feb;105(1):84-91. doi: 10.1016/j.homp.2015.07.002. Epub 2015 Aug 29.
  • Result: This was an open, observational study. Randomly selected general practitioners known to prescribe homeopathic remedies recruited consecutive patients (≥18 years) who were prescribed passionflower. The general practitioner recorded the following data at inclusion: socio-demographic information and severity of anxiety (Hamilton Anxiety Rating Scale or HAM-A); and for each patient: level of anxiety and sleep disturbance. Anxiety and sleep disturbance were reassessed after 4 weeks of treatment using the same scales. A total of 639 patients were engaged by 98 general practitioners. Anxiety was present in 85.4% and 93.3% at baseline, and sleep disturbance was present in 74.0% of cases. A total of 401 patients received only passionflower, while 167 received passionflower + psychotropics. After 4 weeks, mean anxiety scores decreased by more than 7, 12, and 6 points, and sleep disturbance scores decreased by more than 4 points.
• L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Türközü D, Şanlier N. Crit Rev Food Sci Nutr. 2017 May 24;57(8):1681-1687. doi: 10.1080/10408398.2015.1016141.
  • Result: The health effects of the amino acid theanine, which is a non-protein amino acid unique to tea, have become prominent in recent years. It has been proven that theanine in tea has positive effects especially on relaxation, cognitive performance, emotional status, sleep quality, cancer, cardiovascular diseases, obesity, and colds.
• Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs Hamid HA, Ramli AN, Yusoff MM. Front Pharmacol. 2017 Feb 28;8:96. doi: 10.3389/fphar.2017.00096. eCollection 2017.
• Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms Aman U, Subhan F, Shahid M, Akbar S, Ahmad N, Ali G, Fawad K, Sewell RD. BMC Complement Altern Med. 2016 Feb 24;16:77. doi: 10.1186/s12906-016-1048-6.
• Mechanistic evidence of Passiflora edulis (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed via LC-MS and chemometrics Otify A, George C, Elsayed A, Farag MA. Food Funct. 2015 Dec;6(12):3807-17. doi: 10.1039/c5fo00875a. Epub 2015 Oct 5.
• Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. White DJ, de Klerk S, Woods W, Gondalia S, Noonan C, Scholey AB. 2016 Jan 19;8(1). pii: E53. doi: 10.3390/nu8010053.
• Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double-blind, placebo-controlled trial. Kardashev A, Ratner Y, Ritsner MS. Clin Schizophr Relat Psychoses. 2015 Jul 28.
• A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Dodd FL, Kennedy DO, Riby LM, Haskell-Ramsay CF. Psychopharmacology (Berl). 2015 Jul;232(14):2563-76. doi: 10.1007/s00213-015-3895-0. Epub 2015 Mar 13.