ImmunoGalaktan

Why Arabinogalactan – Superior Support for the Immune System

A combination of 5 plant extracts synergized with vitamin D3 and minerals copper, zinc, and selenium, all working together to contribute to the normal function of the immune system, protect cells from oxidative stress, and support normal energy-yielding metabolism.

Behind the complex name arabinogalactan lies a highly branched polysaccharide composed of a galactan backbone with side chains of galactose and arabinose sugars. It reaches the intestines undigested, making it compatible with beta glucan.

For decades, arabinogalactan has attracted scientists’ attention in their research on the immune system and various other health issues.

Research has shown that arabinogalactan enhances the body’s potential to defend against cold infections, with results indicating a 23% reduction in cold incidence*.

Arabinogalactan is an excellent source of dietary fiber and has been approved by the FDA, receiving GRAS status (Generally Recognized as Safe) in 2000.

Furthermore, it has been proven that consuming arabinogalactan from larch significantly improves beneficial gut microflora, particularly increasing anaerobic probiotic bacteria such as Bifidobacterium and Lactobacillus acidophilus.

According to research published in a scientific article*, clinical studies have shown that using arabinogalactan reduces the likelihood of cold symptoms and strengthens immune function by stimulating immune cells. On the other hand, beta glucan stimulates natural NK (natural killer) cells and macrophages, promoting the secretion of anti-inflammatory cytokines.

Our immune system is busy keeping out external factors like viruses, bacteria, and other microbes. By paying attention to the quality of the food consumed and carefully selecting adequate dietary supplements, you can provide your immune system with the necessary energy and strength, keeping the body protected from harmful pathogens.

Thus, we can say that a healthy immune system is a fundamental prerequisite for human health!

• Have a weakened immune response
• Are prone to infections and colds
• Feel chronic fatigue and exhaustion
• Wish to regularly use natural dietary supplements

Quantities in recommended daily dose (= 2 capsules)

*DV – percentage daily value

Ingredients: Dry extract of Larch tree (Larix gmelinii) standardized to at least 80% arabinogalactan, thickener: hydroxypropyl methylcellulose (capsule), beta-(1,3)(1,6)-D-glucan from yeast (Saccharomyces cerevisiae) min. 90%, dry extract of Astragalus root (Astragalus membranaceus) standardized to at least 70% polysaccharides, dry extract of Siberian ginseng rhizome (Eleutherococcus senticosus) standardized to at least 0.8% eleutherosides, dry extract of Reishi mushroom (Ganoderma lucidum) standardized to at least 10% polysaccharides, anti-caking agent: cellulose powder (ARBOCEL® A300), zinc bisglycinate, copper (II) sulfate pentahydrate, cholecalciferol, sodium selenite.

Analiza na zdravstvenu ispravnost: ImmunoGalaktan

• Grube B, Stier H, Riede L, Gruenwald L. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Scie 2012;3:1533–8.
  • Result: In a clinical trial, the tolerability of the protected arabinogalactan preparation from larch was investigated: 199 healthy participants were randomly assigned to receive either placebo or arabinogalactan. A total of 16 adverse events were observed in 16 participants, with no difference between the group receiving arabinogalactan and placebo. There were no differences in the mean changes of measured biochemical and laboratory parameters. The tolerability of the arabinogalactan extract was rated as “very good” or “good” by researchers for 99% of participants and by 98% of participants in self-assessment, with no statistical differences compared to placebo.
• Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev 2002;7(2):138–49.
  • Result: 48 healthy volunteers were randomly assigned to one of six groups: standardized extract of E. purpurea (EP); ultra-purified E. purpurea/E. angustifolia (urEPA); E. purpurea/E. angustifolia (EPA); E. purpurea/E. angustifolia plus larch arabinogalactan (EPALA); larch arabinogalactan (LA); or placebo. Properdin complement increased by 21% in the EPA group (p<0,05) and by 18% in the EPALA group (p<0,05), compared to the placebo group (p>0,05). SF-36 showed improvements in overall physical health, vitality, and emotional health in the same two groups (EPA and EPALA).
• Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections, Nutrition 28:665-669.
  • Result: 100 healthy individuals were randomized to receive either 250 mg of Wellmune once daily or an identical rice flour-based placebo. 97 participants completed the study. Wellmune tended to reduce the total number of days with URTI symptoms. The ability for “easy breathing” was significantly improved in the Wellmune group; other severity ratings did not show significant differences. Cytokines and chemokines did not differ between groups at the beginning of the study or at day 90, but monocyte chemotactic protein-1 was lower in the Wellmune group during URTI.
• P. D’Adamo, Larch Arabinogalactan, Journal of Naturopathic Medicine, Vol. 6, No. 1, 1996, pp. 33-37.
• De Andrade E, De Mesquita AA, De Almeida Claro J. i sur. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian J Androl 2007;9:241-244.
• Antonova GF, Usov AI. Structure of an arabinogalactan from the wood of the Siberian larch (Larix sibirica Ledeb.). Sov J Bioorganic Chem 1984; 10(12):907–12
• D’Adamo P. Larch arabinogalactan. J Naturopath Med 1996;4:32–9.
• Yakkot M, Salem A, Helmy S. Effect of Memo, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment. Clinical Inerventions in Aging 2013;8:975-981.
• Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory infections. Curr Med Res Opin 2013;29(3):251–8.
• Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32.
• Hauer J, Anderer FA. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol Immunother 1993;36(4):237–44.
• Choi EM, Kim AJ, Kim YO, Hwang JK. Immunomodulating activity of arabinogalactan and fucoidan in vitro. J Med Food 2005;8(4):446–53.
• Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine 2003;10(2-3):145–53.
• Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise, Journal of Dietary Supplements, Early Online:1–13, 2013.
• Brown, G.D. and Gordon, S. 2001. Immune recognition: a new receptor for β-glucans. Nature 413:36.
• Grieshop CM, Flickinger EA, Fahey Jr GC. Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs. J Nutr 2002;132(3):478–82.
• Kathy K Auyeung, Quan-Bin Han, Joshua K Ko 10.1142/S0192415X16500014. Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers
• Yan Qi, Feng Gao, Lifei Hou, Chunping Wan 10.1142/S0192415X1750063X Anti-Inflammatory and Immunostimulatory Activities of Astragalosides
• Xin Wang 1, Zhibin Lin 10.1007/978-981-32-9421-9_1 Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism
• Marzorati M, Verhelst A, Luta G, Sinnott R, Verstraete W, Van de Wiele T, et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139(3):168–76.