What are beta-glucans and how do they work?
Source:
(http://www.inpharma.hr/index.php/news/653/19/Imunomodulatorni-ucinci-beta-glukana)
Beta-glucans are structural homopolysaccharides from the cell walls of fungi and yeasts, but also from cereals (oats and barley) from which they can be isolated. From a chemical point of view, the backbone of the linear structure of the beta-glucan polymer consists of monomers of D-glucose molecules, interconnected by specific beta-1,3/1,6-glycosidic bonds. Therefore, we can more accurately call beta-glucans beta-1,3/1,6-(D)-glucans.
In general, it can be said that beta-1,3/1,6-glucans strengthen the first “line of defense” of the organism. Namely, their main biological immunomodulating action is based precisely on the stimulation of the activity of innate immunity factors. Macrophage activation is definitely a key moment in the activation of factors of innate non-specific immunity. This activation is achieved by the binding of beta-glucan to several specific macrophage receptors.
Activated macrophages have an increased ability to find, recognize and destroy pathogens.
In addition to stimulating phagocytosis, beta-glucans also have the ability to stimulate hematopoiesis. Enhanced hematopoiesis includes stimulation of leukocyte and platelet production.
When are they most commonly used?
- for high cholesterol, diabetes,
- to boost the immune system,
- for chronic fatigue and exhaustion,
- as therapy for oncological indications,
- for infectious diseases such as respiratory tract infections, fungal infections, bacterial infections, viruses.
Why is high purification important for beta-glucans?
Purification, i.e., the removal of manoproteins and lipids from the yeast cell wall during the production process, is imperative to achieve increased bioavailability. It is considered that the minimal requirements for adequate efficacy of beta-glucan application include a purity level and extraction and purification of at least 70-85% beta-glucans.
What is the recommended daily dosage for Beta Glucan & C3 Reduct?
For Beta Glucan & C3 Reduct it is recommended to take 1 to 3 capsules per day, preferably half an hour before meals. With preventive intake, it is possible, in adults, to use beta glucans for a longer period of time. For an increased daily dose, consult a doctor or pharmacist.
Are there any restrictions on taking beta-glucans?
People taking medication should consult their doctor before taking beta-glucans. They are not recommended for pregnant or nursing women.
What is the active compound in olive leaf extract responsible for therapeutic action?
Oleuropein is the most active medicinal compound in olive leaves, responsible for the bitterness of the fruit and the therapeutic action it is mainly associated with. Compounds present in olive leaves are generally believed to strengthen the immune system, and numerous scientific studies attribute various biological effects to oleuropein – antioxidant, antimicrobial, anti-inflammatory, antiviral, cytotoxic. Scientists cite up to 126 pathogenic microorganisms that cannot resist the action of compounds present in olive leaf extract, many of which have already become resistant to antibiotic action.
Can olive leaf extract help with hypertension and prevent the oxidation process of LDL cholesterol, known as "bad cholesterol"?
Yes! The European Food Safety Authority (EFSA), in a document published in 2011 (EFSA Journal 2011;9(4):2033), confirmed the influence of oleuropein and olive leaf extract in preventing the oxidation process of LDL (low-density lipoprotein, “bad cholesterol”), which is associated with the formation of plaques on the walls of blood vessels.
Today, olive leaf is one of the few herbal medicines clinically tested in the treatment of hypertension.
Why use turmeric extract?
Turmeric has a rich history in India as a spice, preservative, and coloring agent, and for centuries it has been used in highly esteemed Eastern medicine, Ayurveda, where its effects as a natural remedy are well-documented. The intense yellow color is defined by curcumin, the active ingredient in the curcuminoid group, which is attributed with strong anti-inflammatory, antiviral, antibacterial, and antioxidant properties. Curcumin, along with its active compound, has been the subject of over 13,000 published biomedical studies, which have investigated its effects on various inflammations, arthritis, various forms of cancer, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and stroke. At the molecular level, curcuminoids have shown the ability to inhibit nuclear factor kappa B (NF-kB), a transcription factor that causes and drives various inflammations. NF-kB is involved in various chronic diseases and conditions ranging from cardiovascular diseases to cancer. Curcuminoids have significant antioxidant, antiviral, antibacterial, and anti-inflammatory effects, support a healthy immune system, and inhibit destructive enzymes in joints and tissues (Aggarwal B. et al. (2006). Turmeric: The Genus Curcuma. Pp 297-368).
What is the advantage of the turmeric extract Curcumin C3 Reducta?
Curcumin C3 Reduct je registrirani zaštitni znak za tetrahidrokurkuminoide dobivene iz 99% turmeric extract. Tetrahydrocurcuminoids arethe main metabolites of curcuminoids. These are colorless hydrogenated compounds derived from Curcumin C3 Complex® curcuminoids: curcumin, demethoxycurcumin and bisdemethoxycurcumin. Tetrahydrocurcuminoids present in
Curcumin C3 Reduct® has a better absorption profile in the intestines, better stability at physiological pH and stronger biological activity than parent curcuminoids. Black pepper is not needed for their excellent absorption.